منابع مشابه
Tissue Specific Expression of Human Calcitonin Gene in Potato Tubers by an Organ Specific Promoter
To increase the production level of heterologous proteins in plants, strategies such as choice of strongerpromoters, optimization of codon usage and specific localization of foreign proteins are of major concern.Calcitonin (CT), a 32 amino acid polypeptide is a powerful and specific inhibitor of bone resorption and isused to treat several human diseases. Calcitonin activity is...
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Dale J. Voeks1, Gary A. Clawson2, and James S. Norris1 1Medical University of South Carolina, Charleston, SC; 2Penn State University, Hershey, PA __________________________________________________________________________________________________ Correspondence: Dr. James S. Norris, Department of Microbiology and Immunology, Medical University of South Carolina, 171 Ashley Avenue, Charleston, Sou...
متن کاملUnderstanding Tissue-Specific Gene Regulation.
Although all human tissues carry out common processes, tissues are distinguished by gene expression patterns, implying that distinct regulatory programs control tissue specificity. In this study, we investigate gene expression and regulation across 38 tissues profiled in the Genotype-Tissue Expression project. We find that network edges (transcription factor to target gene connections) have hig...
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In order to realise the full potential of cancer suicide gene therapy that allows the precise expression of suicide gene in cancer cells, we used a tissue specific Epithelial cell adhesion molecule (EpCAM) promoter (EGP-2) that directs transgene Herpes simplex virus-thymidine kinase (HSV-TK) expression preferentially in EpCAM over expressing cancer cells. EpCAM levels are considerably higher in...
متن کاملTissGDB: tissue-specific gene database in cancer
Tissue-specific gene expression is critical in understanding biological processes, physiological conditions, and disease. The identification and appropriate use of tissue-specific genes (TissGenes) will provide important insights into disease mechanisms and organ-specific therapeutic targets. To better understand the tissue-specific features for each cancer type and to advance the discovery of ...
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ژورنال
عنوان ژورنال: Nature Biotechnology
سال: 1996
ISSN: 1087-0156,1546-1696
DOI: 10.1038/nbt0496-438